Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases

Loxosceles spider venom contains Sphingomyelinase D (SMase D), the key toxin causing pathology. SMase D hydrolyzes the main component of lipid rafts, sphingomyelin, which changes the membrane microenvironment resulting in the activation of endogenous metalloproteinase from the ADAMs family. Alterati...

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Detalles Bibliográficos
Autores principales: Lopes, Priscila Hess, van den Berg, Carmen W., Tambourgi, Denise V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237637/
https://www.ncbi.nlm.nih.gov/pubmed/32477123
http://dx.doi.org/10.3389/fphar.2020.00636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237637/
https://www.ncbi.nlm.nih.gov/pubmed/32477123
http://dx.doi.org/10.3389/fphar.2020.00636

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