A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

Therapeutic hypothermia (TH) is standard treatment for neonates (≥36 weeks) with perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and neurodevelopmental disability due to reduced metabolic rate and decreased neuronal apoptosis. Since both hypothermia and PA influence...

Descripción completa

Detalles Bibliográficos
Autores principales: Smits, Anne, Annaert, Pieter, Van Cruchten, Steven, Allegaert, Karel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237643/
https://www.ncbi.nlm.nih.gov/pubmed/32477113
http://dx.doi.org/10.3389/fphar.2020.00587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237643/
https://www.ncbi.nlm.nih.gov/pubmed/32477113
http://dx.doi.org/10.3389/fphar.2020.00587

Ejemplares similares