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A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

Therapeutic hypothermia (TH) is standard treatment for neonates (≥36 weeks) with perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and neurodevelopmental disability due to reduced metabolic rate and decreased neuronal apoptosis. Since both hypothermia and PA influence...

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Detalles Bibliográficos
Autores principales:	Smits, Anne, Annaert, Pieter, Van Cruchten, Steven, Allegaert, Karel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237643/ https://www.ncbi.nlm.nih.gov/pubmed/32477113 http://dx.doi.org/10.3389/fphar.2020.00587

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