Synthesis, in vitro and in vivo evaluation of (11)C-O-methylated arylpiperazines as potential serotonin 1A (5-HT(1A)) receptor antagonist radiotracers

BACKGROUND: Serotonin 1A (5-HT(1A)) receptors are implicated in the pathogenesis of several psychiatric and neurodegenerative disorders motivating the development of suitable radiotracers for in vivo positron emission tomography (PET) neuroimaging. The gold standard PET imaging agent for this target...

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Detalles Bibliográficos
Autores principales: Narayanaswami, Vidya, Tong, Junchao, Fiorino, Ferdinando, Severino, Beatrice, Sparaco, Rosa, Magli, Elisa, Giordano, Flavia, Bloomfield, Peter M., Prabhakaran, Jaya, Mann, J. John, Vasdev, Neil, Dahl, Kenneth, Kumar, J. S. Dileep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237647/
https://www.ncbi.nlm.nih.gov/pubmed/32430632
http://dx.doi.org/10.1186/s41181-020-00096-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237647/
https://www.ncbi.nlm.nih.gov/pubmed/32430632
http://dx.doi.org/10.1186/s41181-020-00096-8

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