DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification

In mammals, a subset of arginine tRNA isoacceptors are methylated in the anticodon loop by the METTL2 methyltransferase to form the 3-methylcytosine (m3C) modification. However, the mechanism by which METTL2 identifies specific tRNA arginine species for m3C formation as well as the biological role o...

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Detalles Bibliográficos
Autores principales: Lentini, Jenna M., Alsaif, Hessa S., Faqeih, Eissa, Alkuraya, Fowzan S., Fu, Dragony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237682/
https://www.ncbi.nlm.nih.gov/pubmed/32427860
http://dx.doi.org/10.1038/s41467-020-16321-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237682/
https://www.ncbi.nlm.nih.gov/pubmed/32427860
http://dx.doi.org/10.1038/s41467-020-16321-6

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