The mutational impact of culturing human pluripotent and adult stem cells

Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we determined all mutations in individual human stem cells by whole genome sequencing. Individual pluripotent, intesti...

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Detalles Bibliográficos
Autores principales: Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237696/
https://www.ncbi.nlm.nih.gov/pubmed/32427826
http://dx.doi.org/10.1038/s41467-020-16323-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237696/
https://www.ncbi.nlm.nih.gov/pubmed/32427826
http://dx.doi.org/10.1038/s41467-020-16323-4

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