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Thanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC–LptA Interaction and Decreasing LptA Stability
The outer membrane (OM) of Gram-negative bacteria is a highly selective permeability barrier due to its asymmetric structure with lipopolysaccharide (LPS) in the outer leaflet. In Escherichia coli, LPS is transported to the cell surface by the LPS transport (Lpt) system composed of seven essential p...
Autores principales: | Moura, Elisabete C. C. M., Baeta, Tiago, Romanelli, Alessandra, Laguri, Cedric, Martorana, Alessandra M., Erba, Emanuela, Simorre, Jean-Pierre, Sperandeo, Paola, Polissi, Alessandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237710/ https://www.ncbi.nlm.nih.gov/pubmed/32477309 http://dx.doi.org/10.3389/fmicb.2020.00909 |
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