Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We show that mechanical stretch deforms the nucleus, whi...

Descripción completa

Detalles Bibliográficos
Autores principales: Nava, Michele M., Miroshnikova, Yekaterina A., Biggs, Leah C., Whitefield, Daniel B., Metge, Franziska, Boucas, Jorge, Vihinen, Helena, Jokitalo, Eija, Li, Xinping, García Arcos, Juan Manuel, Hoffmann, Bernd, Merkel, Rudolf, Niessen, Carien M., Dahl, Kris Noel, Wickström, Sara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237863/
https://www.ncbi.nlm.nih.gov/pubmed/32302590
http://dx.doi.org/10.1016/j.cell.2020.03.052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237863/
https://www.ncbi.nlm.nih.gov/pubmed/32302590
http://dx.doi.org/10.1016/j.cell.2020.03.052

Ejemplares similares