Serine mutation of a conserved threonine in the hERG K(+) channel S6-pore region leads to loss-of-function through trafficking impairment

The human Ether-à-go-go Related Gene (hERG) encodes a potassium channel responsible for the cardiac rapid delayed rectifier K(+) current, I(Kr), which regulates ventricular repolarization. Loss-of-function hERG mutations underpin the LQT2 form of congenital long QT syndrome. This study was undertake...

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Detalles Bibliográficos
Autores principales: Al-Moubarak, Ehab, Zhang, Yihong, Dempsey, Christopher E., Zhang, Henggui, Harmer, Stephen C., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237882/
https://www.ncbi.nlm.nih.gov/pubmed/32321643
http://dx.doi.org/10.1016/j.bbrc.2020.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237882/
https://www.ncbi.nlm.nih.gov/pubmed/32321643
http://dx.doi.org/10.1016/j.bbrc.2020.04.003

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