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Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants

Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues maintain mass through feedback loops that balance cell proliferation and removal according to hormone-driven regulatory signa...

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Detalles Bibliográficos
Autores principales: Korem Kohanim, Yael, Tendler, Avichai, Mayo, Avi, Friedman, Nir, Alon, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237888/
https://www.ncbi.nlm.nih.gov/pubmed/32433950
http://dx.doi.org/10.1016/j.immuni.2020.04.022