Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

Human neutrophil elastase (HNE) is a serine protease that degrades matrix proteins. An excess of HNE may trigger several pathological conditions, such as psoriasis. In this work, we aimed to synthesize, characterize and formulate new HNE inhibitors with a 4-oxo-β-lactam scaffold with less toxicity,...

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Detalles Bibliográficos
Autores principales: Nunes, Andreia, Marto, Joana, Gonçalves, Lídia Maria, Simões, Sandra, Félix, Rita, Ascenso, Andreia, Lopes, Francisca, Ribeiro, Helena Margarida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238052/
https://www.ncbi.nlm.nih.gov/pubmed/32295247
http://dx.doi.org/10.3390/pharmaceutics12040358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238052/
https://www.ncbi.nlm.nih.gov/pubmed/32295247
http://dx.doi.org/10.3390/pharmaceutics12040358

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