High BMPR2 expression leads to enhanced SMAD1/5/8 signalling and GDF6 responsiveness in human adipose-derived stem cells: implications for stem cell therapies for intervertebral disc degeneration

Stem cell–based regenerative strategies are promising for intervertebral disc degeneration. Stimulation of bone-marrow- and adipose-derived multipotent stem cells with recombinant human growth differentiation factor 6 (rhGDF6) promotes anabolic nucleus pulposus like phenotypes. In comparison to mese...

Descripción completa

Detalles Bibliográficos
Autores principales: Hodgkinson, Tom, Wignall, Francis, Hoyland, Judith A, Richardson, Stephen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238299/
https://www.ncbi.nlm.nih.gov/pubmed/32489577
http://dx.doi.org/10.1177/2041731420919334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238299/
https://www.ncbi.nlm.nih.gov/pubmed/32489577
http://dx.doi.org/10.1177/2041731420919334

Ejemplares similares