Cargando…

High BMPR2 expression leads to enhanced SMAD1/5/8 signalling and GDF6 responsiveness in human adipose-derived stem cells: implications for stem cell therapies for intervertebral disc degeneration

Stem cell–based regenerative strategies are promising for intervertebral disc degeneration. Stimulation of bone-marrow- and adipose-derived multipotent stem cells with recombinant human growth differentiation factor 6 (rhGDF6) promotes anabolic nucleus pulposus like phenotypes. In comparison to mese...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hodgkinson, Tom, Wignall, Francis, Hoyland, Judith A, Richardson, Stephen M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238299/ https://www.ncbi.nlm.nih.gov/pubmed/32489577 http://dx.doi.org/10.1177/2041731420919334

Ejemplares similares

Combinatorial conditioning of adipose derived‐mesenchymal stem cells enhances their neurovascular potential: Implications for intervertebral disc degeneration
por: Binch, Abbie. L. A., et al.
Publicado: (2019)

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes
por: Minogue, Ben M, et al.
Publicado: (2010)

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
por: Millward-Sadler, S Jane, et al.
Publicado: (2009)

The Mechanisms and Functions of GDF‐5 in Intervertebral Disc Degeneration
por: Guo, Sheng, et al.
Publicado: (2021)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Stem cell horizons in intervertebral disc degeneration
por: Ciacci, Joseph, et al.
Publicado: (2009)

Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration
por: Kibble, Matthew J., et al.
Publicado: (2022)

Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation
por: Hodgkinson, Tom, et al.
Publicado: (2020)

Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc
por: Tolofari, Sotonye K, et al.
Publicado: (2010)

Adipose-Derived Stem Cells (ASCs) for Regeneration of Intervertebral Disc Degeneration: Review Article
por: Romaniyanto, F N U, et al.
Publicado: (2022)

Application of stem cells in the repair of intervertebral disc degeneration
por: Zhang, Wentao, et al.
Publicado: (2022)

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc
por: Purmessur, Devina, et al.
Publicado: (2008)

The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2005)

Mesenchymal Stem Cell for Prevention and Management of Intervertebral Disc Degeneration
por: Longo, Umile Giuseppe, et al.
Publicado: (2012)

Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration
por: Krut, Zoe, et al.
Publicado: (2021)

Stem Cell Therapy and Exercise for Treatment of Intervertebral Disc Degeneration
por: Li, Bo, et al.
Publicado: (2021)

Regulating the fate of stem cells for regenerating the intervertebral disc degeneration
por: Ekram, Sobia, et al.
Publicado: (2021)

Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration
por: Du, Xiaotian, et al.
Publicado: (2023)

Mesenchymal stem cell therapies for intervertebral disc degeneration: Consideration of the degenerate niche
por: Vickers, Louise, et al.
Publicado: (2019)

Degenerate intervertebral disc‐like pH induces a catabolic mechanoresponse in human nucleus pulposus cells
por: Hodson, Nathan W., et al.
Publicado: (2018)

Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration
por: Ligorio, Cosimo, et al.
Publicado: (2022)

Identification of novel nucleus pulposus markers: Interspecies variations and implications for cell-based therapies for intervertebral disc degeneration
por: Rodrigues-Pinto, R., et al.
Publicado: (2013)

Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration
por: Wu, Xinjie, et al.
Publicado: (2022)

Application of stem cells combined with biomaterial in the treatment of intervertebral disc degeneration
por: Liu, Zongtai, et al.
Publicado: (2022)

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration
por: Ohnishi, Takashi, et al.
Publicado: (2023)

Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell
por: Yu, Chao, et al.
Publicado: (2021)

Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research
por: Baumgartner, Laura, et al.
Publicado: (2021)

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
por: Heathfield, Sarah Kathleen, et al.
Publicado: (2008)

Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc
por: Richardson, Stephen M, et al.
Publicado: (2009)

Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration
por: Huang, Huagui, et al.
Publicado: (2023)

How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration
por: Zhang, Qing-Xiang, et al.
Publicado: (2023)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Analysis of Molecular Expression in Adipose Tissue-Derived Mesenchymal Stem Cells : Prospects for Use in the Treatment of Intervertebral Disc Degeneration
por: Jin, Eun-Sun, et al.
Publicado: (2013)

Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future
por: Hoogendoorn, R J W, et al.
Publicado: (2008)

A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration
por: Shu, Cindy C., et al.
Publicado: (2017)

Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target
por: Gilbert, Hamish T. J., et al.
Publicado: (2016)

Characteristics of Stem Cells Derived from the Degenerated Human Intervertebral Disc Cartilage Endplate
por: Liu, Lan-Tao, et al.
Publicado: (2011)

Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells?
por: Loibl, Markus, et al.
Publicado: (2019)

Exosomes derived from stem cells as an emerging therapeutic strategy for intervertebral disc degeneration
por: Hu, Zhi-Lei, et al.
Publicado: (2020)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_quk6pu5brufj9d1tmlq0696cbe