The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids

Pazopanib is a tyrosine kinase inhibitor used to treat renal cell carcinoma. Few in vitro studies investigate its effects towards cancer cells or endothelial cells in the presence of cancer. We tested the effect of Pazopanib on renal cell carcinoma cells (CAKI-2,786-O) in two-dimensional and three-d...

Descripción completa

Detalles Bibliográficos
Autores principales: Stamati, Katerina, Redondo, Patricia A, Nyga, Agata, Neves, Joana B, Tran, Maxine GB, Emberton, Mark, Cheema, Umber, Loizidou, Marilena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Technological Advances in 3D Tissue and Organ Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238304/
https://www.ncbi.nlm.nih.gov/pubmed/32489578
http://dx.doi.org/10.1177/2041731420920597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238304/
https://www.ncbi.nlm.nih.gov/pubmed/32489578
http://dx.doi.org/10.1177/2041731420920597

Ejemplares similares