Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest β-Secretase Enzymatic Activity Involved in Alzheimer's Disease

Proteases BACE1 (β-secretases) enzymes have been recognized as a promising target associated with Alzheimer's disease (AD). This study was carried out on the principles of molecular docking, chemical synthesis, and enzymatic inhibition of BACE1 enzymes via biaryl guanidine-based ligands. Based...

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Detalles Bibliográficos
Autores principales: Ali, Sayyad, Asad, Muhammad Hassham Hassan Bin, Khan, Fahad, Murtaza, Ghulam, Rizvanov, Albert A., Iqbal, Jamshed, Babak, Borhan, Hussain, Izhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238388/
https://www.ncbi.nlm.nih.gov/pubmed/32462027
http://dx.doi.org/10.1155/2020/8934289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238388/
https://www.ncbi.nlm.nih.gov/pubmed/32462027
http://dx.doi.org/10.1155/2020/8934289

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