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Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers
ACE2, in concert with the protease TMPRSS2, binds the novel coronavirus SARS-CoV-2 and facilitates its cellular entry. The ACE2 gene is expressed in SARS-CoV-2 target cells, including Type II Pneumocytes (Ziegler, 2020), and is activated by interferons. Viral RNA was also detected in breast milk (Wu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239044/ https://www.ncbi.nlm.nih.gov/pubmed/32511315 http://dx.doi.org/10.1101/2020.05.11.089045 |