Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses

Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sens...

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Detalles Bibliográficos
Autores principales: Prasanth, K. Reddisiva, Hirano, Minato, Fagg, W. Samuel, McAnarney, Eileen T., Shan, Chao, Xie, Xuping, Hage, Adam, Pietzsch, Colette A., Bukreyev, Alexander, Rajsbaum, Ricardo, Shi, Pei-Yong, Bedford, Mark T., Bradrick, Shelton S., Menachery, Vineet, Garcia-Blanco, Mariano A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239047/
https://www.ncbi.nlm.nih.gov/pubmed/32511318
http://dx.doi.org/10.1101/2020.03.24.005900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239047/
https://www.ncbi.nlm.nih.gov/pubmed/32511318
http://dx.doi.org/10.1101/2020.03.24.005900

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