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Variability in the Log Domain and Limitations to Its Approximation by the Normal Distribution
Pharmacometric models using lognormal distributions have become commonplace in pharmacokinetic–pharmacodynamic investigations. The extent to which it can be interpreted by traditional description of variability through the normal distribution remains elusive. In this tutorial, the comparison is made...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239339/ https://www.ncbi.nlm.nih.gov/pubmed/32198841 http://dx.doi.org/10.1002/psp4.12507 |