A conserved and regulated mechanism drives endosomal Rab transition

Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key proteins involved in their identity, biogenesis, and fusion. Rab activation requires a guanine nucleotide exchange factor (GEF), which is Mon1-Ccz1 for Rab7. During endosome maturation, Rab5 is replaced by Rab7, though the underlyi...

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Detalles Bibliográficos
Autores principales: Langemeyer, Lars, Borchers, Ann-Christin, Herrmann, Eric, Füllbrunn, Nadia, Han, Yaping, Perz, Angela, Auffarth, Kathrin, Kümmel, Daniel, Ungermann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239660/
https://www.ncbi.nlm.nih.gov/pubmed/32391792
http://dx.doi.org/10.7554/eLife.56090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239660/
https://www.ncbi.nlm.nih.gov/pubmed/32391792
http://dx.doi.org/10.7554/eLife.56090

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