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Impaired differentiation of human induced neural stem cells by TOR1A overexpression

DYT-TOR1A is the most common inherited dystonia caused by a three nucleotide (GAG) deletion (dE) in the TOR1A gene. Death early after birth and cortical anomalies of the full knockout in rodents underscore its developmental importance. We therefore explored the timed effects of TOR1A-wt and TOR1A-dE...

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Detalles Bibliográficos
Autores principales: Stengel, Felix, Vulinovic, Franca, Meier, Britta, Grütz, Karen, Klein, Christine, Capetian, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239838/
https://www.ncbi.nlm.nih.gov/pubmed/32239467
http://dx.doi.org/10.1007/s11033-020-05390-x