Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts

Recent evidence has emerged that cancer cells can use various metabolites as fuel sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote metabolic changes leading to enhanced glycolysis or mitochondrial OXPHOS. However, the effect of metabolite-restriction on non-tran...

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Detalles Bibliográficos
Autores principales: Kozlov, Alexandra M., Lone, Asad, Betts, Dean H., Cumming, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239882/
https://www.ncbi.nlm.nih.gov/pubmed/32433492
http://dx.doi.org/10.1038/s41598-020-65193-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239882/
https://www.ncbi.nlm.nih.gov/pubmed/32433492
http://dx.doi.org/10.1038/s41598-020-65193-9

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