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The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis

The pathophysiology of sepsis-induced myocardial dysfunction is not resolved to date and comprises inflammation, barrier dysfunction and oxidative stress. Disease-associated reduction of tissue cystathionine-γ-lyase (CSE) expression, an endogenous H(2)S-producing enzyme, is associated with oxidative...

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Detalles Bibliográficos
Autores principales: Merz, Tamara, Denoix, Nicole, Wigger, Daniela, Waller, Christiane, Wepler, Martin, Vettorazzi, Sabine, Tuckermann, Jan, Radermacher, Peter, McCook, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239997/
https://www.ncbi.nlm.nih.gov/pubmed/32477273
http://dx.doi.org/10.3389/fendo.2020.00299