Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda

Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization. Methods: We enrolled 132 LTBI-positive and 150 LTBI-negativ...

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Detalles Bibliográficos
Autores principales: Lubyayi, Lawrence, Mawa, Patrice A., Nabakooza, Grace, Nakibuule, Marjorie, Tushabe, John Vianney, Serubanja, Joel, Aibo, Dorothy, Akurut, Hellen, Tumusiime, Josephine, Hasso-Agopsowicz, Mateusz, Kaleebu, Pontiano, Levin, Jonathan, Dockrell, Hazel M., Smith, Steven, Webb, Emily L., Elliott, Alison M., Cose, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240028/
https://www.ncbi.nlm.nih.gov/pubmed/32477371
http://dx.doi.org/10.3389/fimmu.2020.00929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240028/
https://www.ncbi.nlm.nih.gov/pubmed/32477371
http://dx.doi.org/10.3389/fimmu.2020.00929

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