Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness. Syndecan-1 is modulated by the heparan sulfate-degrading enzyme heparanase, but the underlying regulatory mechanisms are only poorly u...

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Detalles Bibliográficos
Autores principales: Katakam, Sampath Kumar, Pelucchi, Paride, Cocola, Cinzia, Reinbold, Rolland, Vlodavsky, Israel, Greve, Burkhard, Götte, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240066/
https://www.ncbi.nlm.nih.gov/pubmed/32477959
http://dx.doi.org/10.3389/fonc.2020.00774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240066/
https://www.ncbi.nlm.nih.gov/pubmed/32477959
http://dx.doi.org/10.3389/fonc.2020.00774

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