Cargando…

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness. Syndecan-1 is modulated by the heparan sulfate-degrading enzyme heparanase, but the underlying regulatory mechanisms are only poorly u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katakam, Sampath Kumar, Pelucchi, Paride, Cocola, Cinzia, Reinbold, Rolland, Vlodavsky, Israel, Greve, Burkhard, Götte, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240066/ https://www.ncbi.nlm.nih.gov/pubmed/32477959 http://dx.doi.org/10.3389/fonc.2020.00774

Ejemplares similares

The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties
por: Teixeira, Felipe C. O. B., et al.
Publicado: (2020)

Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling
por: Ibrahim, Sherif A., et al.
Publicado: (2013)

Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src
por: Cohen-Kaplan, Victoria, et al.
Publicado: (2020)

Differential Impact of Membrane-Bound and Soluble Forms of the Prognostic Marker Syndecan-1 on the Invasiveness, Migration, Apoptosis, and Proliferation of Cervical Cancer Cells
por: Hilgers, Katharina, et al.
Publicado: (2022)

A rat mammary gland cancer cell with stem cell properties of self-renewal and multi-lineage differentiation
por: Cocola, Cinzia, et al.
Publicado: (2008)

Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2
por: Gross-Cohen, Miriam, et al.
Publicado: (2021)

Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma
por: Binder Gallimidi, Adi, et al.
Publicado: (2017)

A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane
por: Margulis, Itai, et al.
Publicado: (2021)

Heparanase inhibitors restrain mesothelioma
por: Lapidot, Moshe, et al.
Publicado: (2018)

Heparanase Regulates Levels of Syndecan-1 in the Nucleus
por: Chen, Ligong, et al.
Publicado: (2009)

Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells
por: Maccarana, Marco, et al.
Publicado: (2022)

scMuffin: an R package to disentangle solid tumor heterogeneity by single-cell gene expression analysis
por: Nale, Valentina, et al.
Publicado: (2023)

Forty Years of Basic and Translational Heparanase Research
por: Vlodavsky, Israel, et al.
Publicado: (2020)

Heparanase activates the syndecan-syntenin-ALIX exosome pathway
por: Roucourt, Bart, et al.
Publicado: (2015)

Loss of Syndecan‐1 and Increased Expression of Heparanase in Invasive Esophageal Carcinomas
por: Mikami, Shuji, et al.
Publicado: (2001)

Heparanase Interacts with Resistin and Augments Its Activity
por: Novick, Daniela, et al.
Publicado: (2014)

Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis
por: Tang, Li, et al.
Publicado: (2021)

Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells
por: Sharma, Pankaj, et al.
Publicado: (2022)

The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 Promotes Ovarian Cancer Pathogenesis
por: Hillemeyer, Lara, et al.
Publicado: (2022)

Heparanase Modulates Chromatin Accessibility
por: Li, Honglian, et al.
Publicado: (2023)

Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
por: Batool, Tahira, et al.
Publicado: (2017)

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans
por: Levy-Adam, Flonia, et al.
Publicado: (2008)

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases
por: Zcharia, Eyal, et al.
Publicado: (2009)

Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation
por: Kayal, Yasmin, et al.
Publicado: (2023)

A Versatile Tool for Stable Inhibition of microRNA Activity
por: Pelucchi, Paride, et al.
Publicado: (2013)

Expression of heparanase in soft tissue sarcomas of adults
por: Kazarin, Olga, et al.
Publicado: (2014)

Impact of Heparanase and the Tumor Microenvironment on Cancer Metastasis and Angiogenesis: Basic Aspects and Clinical Applications
por: Vlodavsky, Israel, et al.
Publicado: (2011)

Immunohistochemical Expression of Heparanase Isoforms and Syndecan-1 Proteins in Colorectal Adenomas
por: Waisberg, J., et al.
Publicado: (2016)

Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation
por: Bitan, Menachem, et al.
Publicado: (2010)

The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor
por: Hassan, Nourhan, et al.
Publicado: (2023)

Heparanase overexpression down-regulates syndecan-1 expression in a gallbladder carcinoma cell line
por: Jin, Hao, et al.
Publicado: (2017)

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma
por: Shafat, Itay, et al.
Publicado: (2011)

Heparanase—A single protein with multiple enzymatic and nonenzymatic functions
por: Vlodavsky, Israel, et al.
Publicado: (2023)

Dissociation between Mature Phenotype and Impaired Transmigration in Dendritic Cells from Heparanase-Deficient Mice
por: Benhamron, Sandrine, et al.
Publicado: (2012)

Heparanase and Syndecan-4 Are Involved in Low Molecular Weight Fucoidan-Induced Angiogenesis
por: Haddad, Oualid, et al.
Publicado: (2015)

Heparanase expression upregulates platelet adhesion activity and thrombogenicity
por: Cui, Hao, et al.
Publicado: (2016)

Nephroprotective Effect of Heparanase in Experimental Nephrotic Syndrome
por: Assady, Suheir, et al.
Publicado: (2015)

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage
por: Gross-Cohen, Miriam, et al.
Publicado: (2016)

Role of heparanase 2 (Hpa2) in gastric cancer
por: Liu, Jingjing, et al.
Publicado: (2021)

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression()
por: Singh, Preeti, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5dgrtha459etqq70kregrt0h7l