Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial

Vitamin D deficiency contributes to a multitude of health conditions, but its biological mechanisms are not adequately understood. Untargeted metabolomics offers the opportunity to comprehensively examine the metabolic profile associated with variations in vitamin D concentrations. The objective of...

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Autores principales: Huang, Mengna, Kelly, Rachel S., Kachroo, Priyadarshini, Chu, Su H., Lee-Sarwar, Kathleen, Chawes, Bo L., Bisgaard, Hans, Litonjua, Augusto A., Weiss, Scott T., Lasky-Su, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240965/
https://www.ncbi.nlm.nih.gov/pubmed/32295265
http://dx.doi.org/10.3390/metabo10040151
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author Huang, Mengna
Kelly, Rachel S.
Kachroo, Priyadarshini
Chu, Su H.
Lee-Sarwar, Kathleen
Chawes, Bo L.
Bisgaard, Hans
Litonjua, Augusto A.
Weiss, Scott T.
Lasky-Su, Jessica
author_facet Huang, Mengna
Kelly, Rachel S.
Kachroo, Priyadarshini
Chu, Su H.
Lee-Sarwar, Kathleen
Chawes, Bo L.
Bisgaard, Hans
Litonjua, Augusto A.
Weiss, Scott T.
Lasky-Su, Jessica
author_sort Huang, Mengna
collection PubMed
description Vitamin D deficiency contributes to a multitude of health conditions, but its biological mechanisms are not adequately understood. Untargeted metabolomics offers the opportunity to comprehensively examine the metabolic profile associated with variations in vitamin D concentrations. The objective of the current analysis was to identify metabolites and metabolic pathways associated with plasma 25-hydroxyvitamin D [25(OH)D] concentrations. The current study included children of pregnant women in the Vitamin D Antenatal Asthma Reduction Trial, who had 25(OH)D and global metabolomics data at age 1 and 3 years. We assessed the cross-sectional associations between individual metabolites and 25(OH)D using linear regression adjusting for confounding factors. Twelve metabolites were significantly associated with plasma 25(OH)D concentrations at both age 1 and 3 after correction for multiple comparisons, including three members of the n-6 polyunsaturated fatty acid (PUFA) metabolism pathway (linoleate, arachidonate, and docosapentaenoate) inversely associated with 25(OH)D. These PUFAs along with four other significant metabolites were replicated in the independent Childhood Asthma Management Program (CAMP) cohort. Both vitamin D and n-6 PUFAs are involved in inflammatory processes, and evidence from cell and animal studies demonstrate a plausible biological mechanism where the active form of 25(OH)D may influence n-6 PUFA metabolism. These relationships warrant further investigation in other populations.
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spelling pubmed-72409652020-06-11 Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial Huang, Mengna Kelly, Rachel S. Kachroo, Priyadarshini Chu, Su H. Lee-Sarwar, Kathleen Chawes, Bo L. Bisgaard, Hans Litonjua, Augusto A. Weiss, Scott T. Lasky-Su, Jessica Metabolites Article Vitamin D deficiency contributes to a multitude of health conditions, but its biological mechanisms are not adequately understood. Untargeted metabolomics offers the opportunity to comprehensively examine the metabolic profile associated with variations in vitamin D concentrations. The objective of the current analysis was to identify metabolites and metabolic pathways associated with plasma 25-hydroxyvitamin D [25(OH)D] concentrations. The current study included children of pregnant women in the Vitamin D Antenatal Asthma Reduction Trial, who had 25(OH)D and global metabolomics data at age 1 and 3 years. We assessed the cross-sectional associations between individual metabolites and 25(OH)D using linear regression adjusting for confounding factors. Twelve metabolites were significantly associated with plasma 25(OH)D concentrations at both age 1 and 3 after correction for multiple comparisons, including three members of the n-6 polyunsaturated fatty acid (PUFA) metabolism pathway (linoleate, arachidonate, and docosapentaenoate) inversely associated with 25(OH)D. These PUFAs along with four other significant metabolites were replicated in the independent Childhood Asthma Management Program (CAMP) cohort. Both vitamin D and n-6 PUFAs are involved in inflammatory processes, and evidence from cell and animal studies demonstrate a plausible biological mechanism where the active form of 25(OH)D may influence n-6 PUFA metabolism. These relationships warrant further investigation in other populations. MDPI 2020-04-14 /pmc/articles/PMC7240965/ /pubmed/32295265 http://dx.doi.org/10.3390/metabo10040151 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Mengna
Kelly, Rachel S.
Kachroo, Priyadarshini
Chu, Su H.
Lee-Sarwar, Kathleen
Chawes, Bo L.
Bisgaard, Hans
Litonjua, Augusto A.
Weiss, Scott T.
Lasky-Su, Jessica
Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial
title Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial
title_full Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial
title_fullStr Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial
title_full_unstemmed Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial
title_short Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial
title_sort plasma 25-hydroxyvitamin d concentrations are associated with polyunsaturated fatty acid metabolites in young children: results from the vitamin d antenatal asthma reduction trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240965/
https://www.ncbi.nlm.nih.gov/pubmed/32295265
http://dx.doi.org/10.3390/metabo10040151
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