Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

A novel series of imidazo[2,1-b]thiazole-sulfonyl piperazine conjugates (9aa-ee) has been synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isozyme hCA I, II and trans-membrane tumor-associated isoform hCA IX and hCA XII, taking...

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Detalles Bibliográficos
Autores principales: Manasa, Kesari Lakshmi, Pujitha, Sravya, Sethi, Aaftaab, Arifuddin, Mohammed, Alvala, Mallika, Angeli, Andrea, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240968/
https://www.ncbi.nlm.nih.gov/pubmed/32244413
http://dx.doi.org/10.3390/metabo10040136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240968/
https://www.ncbi.nlm.nih.gov/pubmed/32244413
http://dx.doi.org/10.3390/metabo10040136

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