Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase as its target along with the discovery that genetic knockdown of pyrimidine salvage sensitized cells to GSK983. Because GSK983 is an ineffective antiviral in the...

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Detalles Bibliográficos
Autores principales: Liu, Qi, Gupta, Amita, Okesli-Armlovich, Ayse, Qiao, Wenjie, Fischer, Curt R., Smith, Mark, Carette, Jan E., Bassik, Michael C., Khosla, Chaitan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241336/
https://www.ncbi.nlm.nih.gov/pubmed/32442424
http://dx.doi.org/10.1016/j.chembiol.2020.05.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241336/
https://www.ncbi.nlm.nih.gov/pubmed/32442424
http://dx.doi.org/10.1016/j.chembiol.2020.05.002

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