Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism

Sinomenine (SIN) is an anti-inflammatory alkaloid derived from Sinomenium acutum, and the products sinomenine hydrochloride (SH) tablets and injections have been marketed in China to treat rheumatoid arthritis (RA). Oral administration of SH has shortcomings of gastrointestinal irritation and low bi...

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Detalles Bibliográficos
Autores principales: Shu, Zixuan, Cao, Yingji, Tao, Yaotian, Liang, Xiao, Wang, Fangyuan, Li, Zhi, Li, Zhenbao, Gui, Shuangying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241499/
https://www.ncbi.nlm.nih.gov/pubmed/32329377
http://dx.doi.org/10.1080/10717544.2020.1754524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241499/
https://www.ncbi.nlm.nih.gov/pubmed/32329377
http://dx.doi.org/10.1080/10717544.2020.1754524

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