Structure-function investigation of 3-methylaspartate ammonia lyase reveals substrate molecular determinants for the deamination reaction

The enzymatic reactions leading to the deamination of β-lysine, lysine, or 2-aminoadipic acid are of great interest for the metabolic conversion of lysine to adipic acid. Enzymes able to carry out these reactions are not known, however ammonia lyases (EC 4.3.1.-) perform deamination on a wide range...

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Detalles Bibliográficos
Autores principales: Saez-Jimenez, Veronica, Maršić, Željka Sanader, Lambrughi, Matteo, Shin, Jae Ho, van Havere, Robin, Papaleo, Elena, Olsson, Lisbeth, Mapelli, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241714/
https://www.ncbi.nlm.nih.gov/pubmed/32437404
http://dx.doi.org/10.1371/journal.pone.0233467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241714/
https://www.ncbi.nlm.nih.gov/pubmed/32437404
http://dx.doi.org/10.1371/journal.pone.0233467

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