Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer’s disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca(2+) dysregulation: Therapeutic implications

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive disturbance as a consequence of the loss of cholinergic neurons in the brain, neuritic plaques and hyperphosphorylation of TAU protein. Although the underlying mechanisms leading to these...

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Detalles Bibliográficos
Autores principales: Soto-Mercado, Viviana, Mendivil-Perez, Miguel, Velez-Pardo, Carlos, Lopera, Francisco, Jimenez-Del-Rio, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241743/
https://www.ncbi.nlm.nih.gov/pubmed/32437347
http://dx.doi.org/10.1371/journal.pone.0221669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241743/
https://www.ncbi.nlm.nih.gov/pubmed/32437347
http://dx.doi.org/10.1371/journal.pone.0221669

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