Clinical Drug-Drug Interaction Studies to Evaluate the Effects of a P-Glycoprotein Inhibitor, CYP3A Inhibitors, and a CYP3A Inducer on the Pharmacokinetics of Naldemedine in Healthy Subjects

BACKGROUND: Naldemedine is a peripherally acting μ-opioid receptor antagonist that is indicated to treat opioid-induced constipation. OBJECTIVES: To assess the potential for drug-drug interactions between a single oral dose of naldemedine and the oral P-glycoprotein inhibitor cyclosporine, cytochrom...

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Detalles Bibliográficos
Autores principales: Fukumura, Kazuya, Kawaguchi, Nao, Ishibashi, Toru, Kubota, Ryuji, Tada, Yukio, Ogura, Eriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242238/
https://www.ncbi.nlm.nih.gov/pubmed/32323104
http://dx.doi.org/10.1007/s40261-020-00902-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242238/
https://www.ncbi.nlm.nih.gov/pubmed/32323104
http://dx.doi.org/10.1007/s40261-020-00902-w

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