The Melatonin Receptor Agonist Ramelteon Induces Cardioprotection that Requires MT2 Receptor Activation and Release of Reactive Oxygen Species

PURPOSE: The melatonin receptor (MT) agonist ramelteon has a higher affinity to MT1 than for MT2 receptors and induces cardioprotection by involvement of mitochondrial potassium channels. Activation of mitochondrial potassium channels leads to release of free radicals. We investigated whether (1) ra...

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Detalles Bibliográficos
Autores principales: Stroethoff, Martin, Goetze, Lukas, Torregroza, Carolin, Bunte, Sebastian, Raupach, Annika, Heinen, André, Mathes, Alexander, Hollmann, Markus W., Huhn, Ragnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242242/
https://www.ncbi.nlm.nih.gov/pubmed/32236860
http://dx.doi.org/10.1007/s10557-020-06972-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242242/
https://www.ncbi.nlm.nih.gov/pubmed/32236860
http://dx.doi.org/10.1007/s10557-020-06972-4

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