The aryl hydrocarbon receptor pathway controls matrix metalloproteinase-1 and collagen levels in human orbital fibroblasts

Thyroid eye disease (TED) affects 25–50% of patients with Graves’ Disease. In TED, collagen accumulation leads to an expansion of the extracellular matrix (ECM) which causes destructive tissue remodeling. The purpose of this study was to investigate the therapeutic potential of activating the aryl h...

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Detalles Bibliográficos
Autores principales: Roztocil, Elisa, Hammond, Christine L., Gonzalez, Mithra O., Feldon, Steven E., Woeller, Collynn F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242326/
https://www.ncbi.nlm.nih.gov/pubmed/32439897
http://dx.doi.org/10.1038/s41598-020-65414-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242326/
https://www.ncbi.nlm.nih.gov/pubmed/32439897
http://dx.doi.org/10.1038/s41598-020-65414-1

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