Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart

The ‘translational therapeutic index’ (TTI) is a drug’s ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies are normally undertaken separately. Our aim was to evaluate a novel integ...

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Detalles Bibliográficos
Autores principales: Hesketh, Louise M., Wilder, Catherine D. E., Ranadive, Niraja N., Lytra, Georgia, Qazimi, Patrisia, Munro, Jade S., Ahdi, Nakita, Curtis, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242333/
https://www.ncbi.nlm.nih.gov/pubmed/32439959
http://dx.doi.org/10.1038/s41598-020-65190-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242333/
https://www.ncbi.nlm.nih.gov/pubmed/32439959
http://dx.doi.org/10.1038/s41598-020-65190-y

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