Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients

Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukaemia (CML), can cause lower gastrointestinal (GI) toxicity which is manifested as diarrhoea. The mechanisms are not fully understood. The enteroendocrine signalling compound, serotonin (5-HT), is important for regula...

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Detalles Bibliográficos
Autores principales: Davies, Andrea, Rodriguez-Vicente, Ana Eugenia, Austin, Gemma, Loaiza, Sandra, Foroni, Letizia, Clark, Richard E, Pirmohamed, Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242433/
https://www.ncbi.nlm.nih.gov/pubmed/32439979
http://dx.doi.org/10.1038/s41598-020-65350-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242433/
https://www.ncbi.nlm.nih.gov/pubmed/32439979
http://dx.doi.org/10.1038/s41598-020-65350-0

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