Cohesin Causes Replicative DNA Damage by Trapping DNA Topological Stress

DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress during replication. The activity of the SMC complex...

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Detalles Bibliográficos
Autores principales: Minchell, Nicola Elizabeth, Keszthelyi, Andrea, Baxter, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242899/
https://www.ncbi.nlm.nih.gov/pubmed/32259483
http://dx.doi.org/10.1016/j.molcel.2020.03.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242899/
https://www.ncbi.nlm.nih.gov/pubmed/32259483
http://dx.doi.org/10.1016/j.molcel.2020.03.013

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