Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors

Degradation of high molecular weight hyaluronic acid (HA) in humans is mainly catalyzed by hyaluronidase Hyal1. This enzyme is involved in many pathophysiological processes and therefore appears an interesting target for drug discovery. Until now, only a few inhibitors of human Hyal1 are known due t...

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Detalles Bibliográficos
Autores principales: Lengers, Isabelle, Herrmann, Fabian, Le Borgne, Marc, Jose, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243119/
https://www.ncbi.nlm.nih.gov/pubmed/32224932
http://dx.doi.org/10.3390/ph13040054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243119/
https://www.ncbi.nlm.nih.gov/pubmed/32224932
http://dx.doi.org/10.3390/ph13040054

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