Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs

New therapeutic modalities are needed to address the problem of pathological but undruggable proteins. One possible approach is the induction of protein degradation by chimeric drugs composed of a ubiquitin ligase (E3) ligand coupled to a ligand for the target protein. This article reviews chimeric...

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Detalles Bibliográficos
Autores principales: Ishikawa, Minoru, Tomoshige, Shusuke, Demizu, Yosuke, Naito, Mikihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243126/
https://www.ncbi.nlm.nih.gov/pubmed/32326273
http://dx.doi.org/10.3390/ph13040074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243126/
https://www.ncbi.nlm.nih.gov/pubmed/32326273
http://dx.doi.org/10.3390/ph13040074

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