Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells

Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse β-cells, LDs are prominent in human β-cells. However, the regulation of LD mobilization (lipolysis) in human β-cells remains unclear. We found that glucose increases lip...

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Detalles Bibliográficos
Autores principales: Liu, Siming, Promes, Joseph A., Harata, Mikako, Mishra, Akansha, Stephens, Samuel B., Taylor, Eric B., Burand, Anthony J., Sivitz, William I., Fink, Brian D., Ankrum, James A., Imai, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243295/
https://www.ncbi.nlm.nih.gov/pubmed/32312867
http://dx.doi.org/10.2337/db19-0951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243295/
https://www.ncbi.nlm.nih.gov/pubmed/32312867
http://dx.doi.org/10.2337/db19-0951

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