LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

A growing number of genes associated with Parkinson’s disease are implicated in the regulation of lysosome function, including LRRK2, whose missense mutations are perhaps the most common monogenic cause of this neurodegenerative disease. These mutations are collectively thought to introduce a pathol...

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Detalles Bibliográficos
Autores principales: Sanyal, Anwesha, Novis, Hailey S., Gasser, Emile, Lin, Steven, LaVoie, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243441/
https://www.ncbi.nlm.nih.gov/pubmed/32499675
http://dx.doi.org/10.3389/fnins.2020.00442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243441/
https://www.ncbi.nlm.nih.gov/pubmed/32499675
http://dx.doi.org/10.3389/fnins.2020.00442

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