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Allele-Specific Transcript Abundance: A Pilot Study in Healthy Centenarians

The genetic basis of healthy aging and longevity remains largely unexplained. One hypothesis as to why long-lived individuals do not appear to have a lower number of common-complex disease variants, is that despite carrying risk variants, they express disease-linked alleles at a lower level than the...

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Detalles Bibliográficos
Autores principales: Tindale, Lauren C, Thiessen, Nina, Leach, Stephen, Brooks-Wilson, Angela R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OXFORD UNIVERSITY PRESS 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243586/
https://www.ncbi.nlm.nih.gov/pubmed/31504207
http://dx.doi.org/10.1093/gerona/glz188