Cargando…

Allele-Specific Transcript Abundance: A Pilot Study in Healthy Centenarians

The genetic basis of healthy aging and longevity remains largely unexplained. One hypothesis as to why long-lived individuals do not appear to have a lower number of common-complex disease variants, is that despite carrying risk variants, they express disease-linked alleles at a lower level than the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tindale, Lauren C, Thiessen, Nina, Leach, Stephen, Brooks-Wilson, Angela R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	OXFORD UNIVERSITY PRESS 2020
Materias:	THE JOURNAL OF GERONTOLOGY: Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243586/ https://www.ncbi.nlm.nih.gov/pubmed/31504207 http://dx.doi.org/10.1093/gerona/glz188

Ejemplares similares

Health Trajectories in Swedish Centenarians
por: Vetrano, Davide L, et al.
Publicado: (2020)

Age- and Sex-Dependent Changes of Free Circulating Blood Metabolite and Lipid Abundances, Correlations, and Ratios
por: Di Cesare, Francesca, et al.
Publicado: (2021)

The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study
por: Klinpudtan, Nonglak, et al.
Publicado: (2021)

Examining the Impact of Socioeconomic Position Across the Life Course on Cognitive Function and Brain Structure in Healthy Aging
por: De Looze, Céline, et al.
Publicado: (2023)

Omega-3 Supplementation Improves Isometric Strength But Not Muscle Anabolic and Catabolic Signaling in Response to Resistance Exercise in Healthy Older Adults
por: Dalle, Sebastiaan, et al.
Publicado: (2020)

Fasting Concentrations and Postprandial Response of 1,2-Dicarbonyl Compounds 3-Deoxyglucosone, Glyoxal, and Methylglyoxal Are Not Increased in Healthy Older Adults
por: Herpich, Catrin, et al.
Publicado: (2021)

The Contributions of Fiber Atrophy, Fiber Loss, In Situ Specific Force, and Voluntary Activation to Weakness in Sarcopenia
por: McPhee, Jamie S, et al.
Publicado: (2018)

Sex-Specific Responses of Life Span and Fitness to Variation in Developmental Versus Adult Diets in Drosophila melanogaster
por: Duxbury, Elizabeth M L, et al.
Publicado: (2020)

Maladaptive Changes Associated With Cardiac Aging Are Sex-Specific and Graded by Frailty and Inflammation in C57BL/6 Mice
por: Kane, Alice E, et al.
Publicado: (2020)

The Effects of Graded Levels of Calorie Restriction: XVIII.Tissue-Specific Changes in Cell Size and Number in Response to Calorie Restriction
por: Phillips, Daniel, et al.
Publicado: (2022)

Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations
por: Mamoshina, Polina, et al.
Publicado: (2018)

Do More Recent Born Generations of Older Adults Have Stronger Grip? A Comparison of Three Cohorts of 66- to 84-Year-Olds in the Tromsø Study
por: Strand, Bjørn Heine, et al.
Publicado: (2019)

Polygenic Propensity for Longevity, APOE-ε4 Status, Dementia Diagnosis, and Risk for Cause-Specific Mortality: A Large Population-Based Longitudinal Study of Older Adults
por: Ajnakina, Olesya, et al.
Publicado: (2023)

Frailty Is Associated With Neutrophil Dysfunction Which Is Correctable With Phosphoinositol-3-Kinase Inhibitors
por: Wilson, Daisy, et al.
Publicado: (2020)

Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis
por: Stephen, Ruth, et al.
Publicado: (2021)

Molecular and Functional Changes to Postsynaptic Cholinergic Signaling in the Vestibular Sensory Organs of Aging C57BL/6 Mice
por: Poppi, Lauren A, et al.
Publicado: (2023)

Lipid and Alzheimer’s disease genes associated with healthy aging and longevity in healthy oldest-old
por: Tindale, Lauren C., et al.
Publicado: (2017)

An Automated, Home-Cage, Video Monitoring-based Mouse Frailty Index Detects Age-associated Morbidity in C57BL/6 and Diversity Outbred Mice
por: Ruby, J Graham, et al.
Publicado: (2023)

Cognition in Motion: Evidence for Intact Action Control With Healthy Aging
por: Ruitenberg, Marit F L, et al.
Publicado: (2020)

Muscle and Tendon Contributions to Reduced Rate of Torque Development in Healthy Older Males
por: Quinlan, Jonathan I, et al.
Publicado: (2018)

Financial Exploitation Is Associated With Structural and Functional Brain Differences in Healthy Older Adults
por: Spreng, R. Nathan, et al.
Publicado: (2017)

Two Functionally Distinct Isoforms of TL1A (TNFSF15) Generated by Differential Ectodomain Shedding
por: Mück, Christoph, et al.
Publicado: (2010)

Applications of Cold Temperature Stress to Age Fractionate Caenorhabditis elegans: A Simple Inexpensive Technique
por: Willett, James D., et al.
Publicado: (2010)

Nutritional Geometry Provides Food for Thought
por: Ruth Archer, C., et al.
Publicado: (2009)

Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted Disruption of the Cβ Subunit of Protein Kinase A
por: Enns, Linda C., et al.
Publicado: (2009)

How Long Will My Mouse Live? Machine Learning Approaches for Prediction of Mouse Life Span
por: Swindell, William R., et al.
Publicado: (2008)

Aging, Depot Origin, and Preadipocyte Gene Expression
por: Cartwright, Mark J., et al.
Publicado: (2010)

Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status
por: Haq, Kamran, et al.
Publicado: (2017)

The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue
por: Derous, Davina, et al.
Publicado: (2018)

Pregnancy at Advanced Maternal Age Affects Behavior and Hippocampal Gene Expression in Mouse Offspring
por: Sampino, Silvestre, et al.
Publicado: (2017)

Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis elegans
por: Cai, Huaihan, et al.
Publicado: (2017)

Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition
por: Houghton, David, et al.
Publicado: (2018)

Long-term Persistent Organic Pollutants Exposure Induced Telomere Dysfunction and Senescence-Associated Secretary Phenotype
por: Yuan, Jinghua, et al.
Publicado: (2018)

Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging
por: Baeta-Corral, Raquel, et al.
Publicado: (2018)

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology
por: Shavlakadze, Tea, et al.
Publicado: (2018)

The Effects of Aging on the Regulation of T-Tubular I(Ca) by Caveolin in Mouse Ventricular Myocytes
por: Kong, Cherrie H T, et al.
Publicado: (2018)

DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project
por: Ciccarone, Fabio, et al.
Publicado: (2018)

“Physiological Dysregulation” as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease
por: Arbeev, Konstantin G, et al.
Publicado: (2019)

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging
por: de Lucia, Claudio, et al.
Publicado: (2019)

Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice
por: Zhang, Xiaolei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6l4okcbolhum457urlsbnh39hc