Identification of SYK inhibitor, R406 as a novel senolytic agent

The selective removal of senescent cells by senolytics is suggested as a potential approach to reverse aging and extend lifespan. Using high-throughput screening with replicative senescence of human diploid fibroblasts (HDFs), we identified a novel senolytic drug R406 that showed selective toxicity...

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Detalles Bibliográficos
Autores principales: Cho, Hyun-Ji, Yang, Eun Jae, Park, Joon Tae, Kim, Jae-Ryong, Kim, Eok-Cheon, Jung, Kyong-Jin, Park, Sang Chul, Lee, Young-Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244031/
https://www.ncbi.nlm.nih.gov/pubmed/32379705
http://dx.doi.org/10.18632/aging.103135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244031/
https://www.ncbi.nlm.nih.gov/pubmed/32379705
http://dx.doi.org/10.18632/aging.103135

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