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Neuropeptide Y1 receptor antagonist promotes osteoporosis and microdamage repair and enhances osteogenic differentiation of bone marrow stem cells via cAMP/PKA/CREB pathway

Osteoporosis is a common metabolic bone disorder in the elderly population. The accumulation of bone microdamage is a critical factor of osteoporotic fracture. Neuropeptide Y (NPY) has been reported to regulated bone metabolism through Y1 receptor (Y1R). In this study the effects and mechanisms of Y...

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Detalles Bibliográficos
Autores principales: Xie, Weixin, Li, Fan, Han, Yi, Qin, Yi, Wang, Yuan, Chi, Xiaoying, Xiao, Jie, Li, Zhanchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244071/
https://www.ncbi.nlm.nih.gov/pubmed/32381754
http://dx.doi.org/10.18632/aging.103129