Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies

The δ-opioid receptor (DOP) is an attractive pharmacological target due to its potent analgesic, anxiolytic and anti-depressant activity in chronic pain models. However, some but not all selective DOP agonists also produce severe adverse effects such as seizures. Thus, the development of novel agoni...

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Detalles Bibliográficos
Autores principales: Mann, Anika, Liebetrau, Sophia, Klima, Marie, Dasgupta, Pooja, Massotte, Dominique, Schulz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244497/
https://www.ncbi.nlm.nih.gov/pubmed/32444688
http://dx.doi.org/10.1038/s41598-020-65589-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244497/
https://www.ncbi.nlm.nih.gov/pubmed/32444688
http://dx.doi.org/10.1038/s41598-020-65589-7

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