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Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies
The δ-opioid receptor (DOP) is an attractive pharmacological target due to its potent analgesic, anxiolytic and anti-depressant activity in chronic pain models. However, some but not all selective DOP agonists also produce severe adverse effects such as seizures. Thus, the development of novel agoni...
Autores principales: | Mann, Anika, Liebetrau, Sophia, Klima, Marie, Dasgupta, Pooja, Massotte, Dominique, Schulz, Stefan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244497/ https://www.ncbi.nlm.nih.gov/pubmed/32444688 http://dx.doi.org/10.1038/s41598-020-65589-7 |
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