A cysteine selenosulfide redox switch for protein chemical synthesis

The control of cysteine reactivity is of paramount importance for the synthesis of proteins using the native chemical ligation (NCL) reaction. We report that this goal can be achieved in a traceless manner during ligation by appending a simple N-selenoethyl group to cysteine. While in synthetic orga...

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Detalles Bibliográficos
Autores principales: Diemer, Vincent, Ollivier, Nathalie, Leclercq, Bérénice, Drobecq, Hervé, Vicogne, Jérôme, Agouridas, Vangelis, Melnyk, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244499/
https://www.ncbi.nlm.nih.gov/pubmed/32444769
http://dx.doi.org/10.1038/s41467-020-16359-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244499/
https://www.ncbi.nlm.nih.gov/pubmed/32444769
http://dx.doi.org/10.1038/s41467-020-16359-6

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