A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors

Sortase enzymes are attractive antivirulence drug targets that attach virulence factors to the surface of Staphylococcus aureus and other medically significant bacterial pathogens. Prior efforts to discover a useful sortase inhibitor have relied upon an in vitro activity assay in which the enzyme is...

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Detalles Bibliográficos
Autores principales: Gosschalk, Jason E., Chang, Chungyu, Sue, Christopher K., Siegel, Sara D., Wu, Chenggang, Kattke, Michele D., Yi, Sung Wook, Damoiseaux, Robert, Jung, Michael E., Ton-That, Hung, Clubb, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244523/
https://www.ncbi.nlm.nih.gov/pubmed/32444661
http://dx.doi.org/10.1038/s41598-020-65256-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244523/
https://www.ncbi.nlm.nih.gov/pubmed/32444661
http://dx.doi.org/10.1038/s41598-020-65256-x

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