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A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors
Sortase enzymes are attractive antivirulence drug targets that attach virulence factors to the surface of Staphylococcus aureus and other medically significant bacterial pathogens. Prior efforts to discover a useful sortase inhibitor have relied upon an in vitro activity assay in which the enzyme is...
Autores principales: | Gosschalk, Jason E., Chang, Chungyu, Sue, Christopher K., Siegel, Sara D., Wu, Chenggang, Kattke, Michele D., Yi, Sung Wook, Damoiseaux, Robert, Jung, Michael E., Ton-That, Hung, Clubb, Robert T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244523/ https://www.ncbi.nlm.nih.gov/pubmed/32444661 http://dx.doi.org/10.1038/s41598-020-65256-x |
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